| SC | Source | |
| SC | Science | |
| SC | South Carolina (US postal abbreviation) | |
| SC | System Center (Microsoft) | |
| SC | Star Craft (game) | |
| SC | Service Center | |
| SC | Southern California | |
| SC | Supply Chain | |
| SC | Scene | |
| SC | Sports Center | |
| SC | Source Code | |
| SC | Supply Catalog | |
| SC | Swimming Club | |
| SC | Smart Card | |
| SC | Sierra Club | |
| SC | School Certificate (New South Wales, Australia) | |
| SC | Space Center | |
| SC | Security Council | |
| SC | Student Center | |
| SC | Southern Comfort | |
| SC | Smith College | |
| SC | Santa Cruz (Argentina province; Philippines; California, USA) | |
| SC | Supreme Court | |
| SC | Standing Committee | |
| SC | Support Center | |
| SC | Single Crochet | |
| SC | Special Case | |
| SC | Single Channel | |
| SC | System Control | |
| SC | Sales Consultant | |
| SC | Save the Children | |
| SC | Special Committee | |
| SC | Sailing Club | |
| SC | StarCraft | |
| SC | Short Circuit | |
| SC | Seychelles (ISO country code, top level domain) | |
| SC | Senior Citizen | |
| SC | Sin City (comic/movie) | |
| SC | Soft Computing (fuzzy logic, neural networks, evolutionary computation) | |
| SC | Senior Consultant | |
| SC | Steering Committee | |
| SC | Sisters of Charity | |
| SC | Single Cell | |
| SC | Stem Cell | |
| SC | Soft Cover (publishing) | |
| SC | Santa Catarina (Brazilian state) | |
| SC | Service Control | |
| SC | Stanley Cup (hockey) | |
| SC | Scientific Committee | |
| SC | Service Code (Bellcore) | |
| SC | Solar Cell (electronics) | |
| SC | Second Coming | |
| SC | Supreme Commander (gaming) | |
| SC | System Controller | |
| SC | Safety Car (auto racing) | |
| SC | Semiconductor | |
| SC | Santa Claus | |
| SC | San Clemente (California) | |
| SC | Scheduled Caste (India) | |
| SC | SimCity (game) | |
| SC | Spinal Cord | |
| SC | Supercharger | |
| SC | Securities Commission | |
| SC | Southwestern College (Winfield, Kansas) | |
| SC | Senior Counsel (Australian equivalent of English Queens Counsel) | |
| SC | Shortcut | |
| SC | Splinter Cell (video game) | |
| SC | Sexual Content (movie subrating) | |
| SC | Single Coil (guitar pickup) | |
| SC | Secure Channel | |
| SC | Scooby Doo (cartoon dog) | |
| SC | Subcommittee | |
| SC | State Coordinator | |
| SC | Safety Class | |
| SC | Sea Cadets | |
| SC | Schizophrenia | |
| SC | Solid Core | |
| SC | Sickle Cell | |
| SC | Signal Corps | |
| SC | Saint Kitts & Nevis | |
| SC | Spell Check | |
| SC | Subcutaneous | |
| SC | SuperCars (website) | |
| SC | SportsCenter (ESPN television news program) | |
| SC | Students' Council | |
| SC | Steeplechase (track and field) | |
| SC | Storm Center | |
| SC | Signal Conditioning | |
| SC | Scandium | |
| SC | Single Carrier | |
| SC | SHOUTcast | |
| SC | Splinter Cell (game) | |
| SC | Sound Canvas (Roland music) | |
| SC | Subcontractor | |
| SC | Sean Connery (actor) | |
| SC | Service Change | |
| SC | Soft-Coated (Wheaten Terrier type) | |
| SC | Sociedade Civil | |
| SC | Software Component | |
| SC | Sports Coupe (car) | |
| SC | Soft Core | |
| SC | Santé Canada (Health Canada) | |
| SC | Scan Converter | |
| SC | Soul Calibur (Dreamcast Game) | |
| SC | Space Charge | |
| SC | Subcontract | |
| SC | St. Christopher-Nevis | |
| SC | Super Computer | |
| SC | Sustainable Communities | |
| SC | Speed Controller | |
| SC | Scilicet | |
| SC | Swarthmore College (Swarthmore, Pennsylvania) | |
| SC | Seattle Center | |
| SC | Safety Certificate (Australia) | |
| SC | Solar Cycle | |
| SC | SuperCard (computer software) | |
| SC | Section Chief (Order of the Arrow, Boy Scouts of America) | |
| SC | Single Column | |
| SC | Software Composition (Symposium) | |
| SC | Supply Corps | |
| SC | Silver Certificate (currency) | |
| SC | Sacred Cow | |
| SC | Samurai Champloo (anime series) | |
| SC | Spatial Cognition (International Conference) | |
| SC | SuperCoupe (Ford Thunderbird model) | |
| SC | Something Corporate (band) | |
| SC | Sub C (battery) | |
| SC | Standardbred Canada (harness racing) | |
| SC | Stepchild | |
| SC | Stray Cat | |
| SC | Static Context (decompressor state) | |
| SC | Sterling College (Sterling, Kansas) | |
| SC | Seguridad Ciudadana (Guatemala special police task force) | |
| SC | Stratum Corneum (top layer of the skin) | |
| SC | Service Capability | |
| SC | Security Cooperation | |
| SC | Space Camp | |
| SC | Brothers of the Sacred Heart (religious order) | |
| Sc | Secondary Containment | |
| SC | Sample Check | |
| SC | Stratocumulus (cloud formation) | |
| SC | Small Capital (letter) | |
| SC | Sclerosing Cholangitis | |
| SC | Spontaneous Combustion (movie, chemistry, hot sauce brand) | |
| SC | Shading Coefficient | |
| SC | Star Control (game) | |
| SC | Stachybotrys Chartarum (straw mold) | |
| SC | System Concept | |
| SC | Superior Colliculus (part of the eye) | |
| SC | Service Configuration (Sprint) | |
| SC | Sprint Cellular | |
| SC | Storage Capability | |
| SC | Stair Climbing (aerobic exercise) | |
| SC | Small Colony (mycoplasma) | |
| SC | Selection Criterion | |
| SC | Secret Crush | |
| SC | Southern Cone (geography) | |
| SC | Strike Commander | |
| SC | Security Category (National Institute of Standards & Technology) | |
| SC | Senior Controller | |
| SC | Station Chief | |
| SC | Session Control | |
| SC | Servicio Civil (Spanish) | |
| SC | Service Channel | |
| SC | Scoring Criteria | |
| SC | Small Crown (British watermark; philately) | |
| SC | Standard Connector (Fiber Connector) | |
| SC | Safety Computer | |
| SC | Sales Charge | |
| SC | Shaped Charge | |
| SC | Station Commander | |
| SC | Sculpsit (Latin: formed by; inscription on sculptures etc., followed by the name) | |
| SC | Standards Conformance | |
| SC | Specialty Course | |
| SC | Subject Centre (UK) | |
| SC | Special Communication (formal memo) | |
| SC | Small Computers | |
| SC | Switch Command (NEC) | |
| SC | Space Channel | |
| SC | Solution Consultant | |
| SC | Secondary Channel (ITU-T) | |
| SC | Sam Cassell (NBA Player) | |
| Sc | Schmidt Number (kinetic viscosity/molecular diffusivity) | |
| SC | Surface Combatant (warship) | |
| SC | Solclaim (gaming, Asheron's Call) | |
| SC | Subreality Cafe | |
| SC | Stream Class | |
| SC | sternoclavicular joint | |
| SC | Soul Coughing (band) | |
| SC | Sulfonyl Chloride | |
| SC | Specialty Code | |
| SC | Signal Center | |
| SC | Start Conversion | |
| SC | Successful Cross (soccer) | |
| SC | Supercalendered (paper type) | |
| SC | Steam Chest | |
| SC | Sony Center | |
| SC | Scott Catalogue (philatelic catalog) | |
| SC | Scrotal Circumference (livestock) | |
| SC | Stuck Closed | |