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Single-Cell Pharmacodynamic Monitoring of Ribosomal Protein S6 Phosphorylation During AC220 Therapy Demonstrates In Vivo FLT3 Inhibition in Circulating Leukemic Blasts and Accurately Detects the Development of AC220 Resistance(abstract #2453) will be presented by the University of Pennsylvania's Alexander Perl, M.
The latest additions to the LANCE Ultra kinase offering are: * ULight[TM]-eIF4E-binding protein 1 (Thr37/46) Peptide * Europium-anti-phospho-eIF4E-binding protein 1 (Thr37/46) * ULight[TM]-phospho-40S Ribosomal Protein S6 (pSer235/Ser236) Peptide * Europium-anti-phospho-40S Ribosomal Protein S6 (Ser235/236) * ULight[TM]-DNA Topoisomerase 2-alpha (Thr1342) Peptide * Europium-anti-phospho-DNA Topoisomerase 2-alpha (Thr1342) * Europium-anti-phospho-MAP Kinase p38-alpha (Thr179/Tyr181) Combining these new substrates and antibodies increases the number of kinases that can be tested with the LANCE Ultra assay platform to 310 enzymes.