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The correct cytoplasmic localization of mRNAs and their transport and silencing in messenger ribonucleoprotein particles (mRNPs), is dependent on the earliest steps of mRNA processing in the nucleus.
After a historical treatise on the field, the general attributes and telomeres and telomerases and the relation of telomere biology to human health are discussed in chapters on the telomerase ribonucleoprotein particle, telomerase biochemistry and biogenesis, telomerase and human cancer, modeling cancer and aging in the telomerase-deficient mouse, telomerase deficiency and human disease, telomerase-independent maintenance of mammalian telomeres, telomerase-independent telomere maintenance in yeas, meiotic telomeres, telomere position effect, and telomere structural biology.