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This capability is critical to maintaining a cell's resting potential and in controlling cell excitability," said Dr.
The Ionic Basis of the Resting Potential Before we can understand the ionic basis of the action potential, we must first understand the ionic basis of the resting potential and ask, How do the ion concentrations in the cell and extracellular milieu affect membrane potential?
These channels underlie a potassium current called the M-current, which is important in the regulation of the resting potential and electrical firing of certain nerve cells.