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Lessons learned from the CIIT research that impact carcinogen testing and risk assessment: * Toxicity and tissue repair should be repaired in selecting doses for cancer studies; * Bolus gavage dosing is suspect and may provide results that cannot be extrapolated to environmental exposures, such as drinking water; * In interpreting cancer studies, cell damage, cell killing, and regenerative cell proliferation may be the driving force in tumor formation at both the MTD and one-half the MTD; * For chemicals that do not react with DNA, it is not appropriate to use the linearated multistage model to extrapolate cancer risks from high toxic doses t lower nontoxic exposures.