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Samples in periodicals archive:
PHARMACOLOGY Drotrecogin alfa (activated) is a recombinant human activated protein C (9).
This press release is transmitted on behalf of Eli Lilly and Company Indiamapolis - Eli Lilly and Company (NYSE: LLY) announced today that it is stopping enrollment in a Phase III clinical trial investigating the therapeutic potential of recombinant human activated protein C in the treatment of severe sepsis.
Three natural anticoagulants have been tested in large phase III trials in sepsis: recombinant human activated Protein C, tissue factor pathway inhibitor and antithrombin.
The CPMP, comprised of regulators from 15-member countries, based its positive opinion on the results of an international Phase III clinical trial (known as PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis), which were published March 8, 2001 in The New England Journal of Medicine.
The approval was based on the results of a landmark, international Phase III clinical trial (known as PROWESS, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis), which were published March 8, 2001, in New England Journal of Medicine.