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ArQule's lead product, in Phase 2 and Phase 3 clinical development, is tivantinib (ARQ 197), an oral, selective inhibitor of the c-MET receptor tyrosine kinase.
Receptor selective retinoids, receptor tyrosine kinase inhibitors (TKIs), SERMs, Cox-2 inhibitors, and others are some of the promising novel agents for the prevention of breast cancer.
Of potential clinical significance, treating mice xenografted to bear a human KRAS mutant colorectal cancer cell line with a combination of a receptor tyrosine kinase inhibitor and a MEK inhibitor induced tumor regression.
Eph receptor tyrosine kinases and their ligands, the ephrins, are involved in a variety of biological processes, including normal embryonic development, cell adhesion, cell migration, tissue morphogenesis, angiogenesis and cancer.
Abstract EphB4 is a receptor tyrosine kinase that is expressed on epithelial cells during fetal life.
Mutations in the KIT receptor tyrosine kinase give rise to the critical transforming oncoprotein in 85% of gastrointestinal stromal tumors (GISTs).
Soon after it was recognized as a growth factor-like molecule, as it interacted with receptor tyrosine kinases (RTKs) of the TAM family; Tyro3, Axl, and MerTK.
00 Hardcover QP41 A special section is included in this year's edition on [Beta]-arrestins with topics that include the role of [Beta]-arrestin-mediated signaling in chemotaxis cellular process, their role in regulating signaling by receptor tyrosine kinases (RTKs), and the role of G protein- coupled receptor kinases and arrestins.