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In the first part of the pooled analysis, they examined the QT interval -describes a segment of the heart's rhythm on an electrocardiogram; when prolonged, it can cause serious irregular heartbeats or sudden cardiac death - of 93 people who had just consumed one to three cans of energy drinks.
Due to incidents of prolongation of the QT interval of the ECG following Zofran administration, the manufacturer, GlaxoSmithKline, was required by the FDA to conduct a study to assess this particular risk.
QT interval is measured with an electrocardiogram (ECG) and varies with the heart rate - it gets longer when the heart beats slower and is shorter when the heart beats faster.
Introduction Prolongation of the QT interval is a rarely seen side effect of moxifloxacin, and in severe cases it may trigger fatal arrhythmias such as Torsades de Pointes (TdP) (1,2).
MATERIALS AND METHODS A comprehensive analysis of QT interval assessments including the QTc interval was performed in AMP-516 per ICH E14 Guidance: Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Anti-arrhythmic Drugs (October 2005, ICH).
Two dynamic properties of VR, the QT interval variability at 24-hour ECG recording (QTV) and QT interval rate-adaptation, have undergone more intensive investigation in recent years in order to assess their utility for high-risk patient identification.
Prolongation of the QT interval may lead to a condition known as torsades de pointes, an abnormal heart rhythm.
The QT interval was defined as between the beginning of the QRS complex and the place where T waves descend onto the TP isoelectric line9.