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CASE SUMMARY An 84-year-old woman presented with hemoptysis during an elective right-heart catheterization when a pulmonary capillary wedge pressure measurement was performed.
4 Aspartate aminotransferase (U/L) 86 95 138 145 Alanine aminotransferase (U/L) 92 118 156 205 Mean right atrial pressure (mm Hg) Right ventricular pressure (mm Hg) Pulmonary artery pressure (mm Hg) Mean pulmonary capillary wedge pressure (mm Hg) Day Variable 4 * 4 5 ([dagger]) Maximum temperature ([degrees]F) 98.
However, during a peak cardiopulmonary exercise test one glaring difference between the two groups became evident: All 10 subjects with diabetes demonstrated a significantly greater increase in pulmonary capillary wedge pressure than controls.
Sildenafil has also been evaluated in heart failure with reductions in PAP and pulmonary capillary wedge pressure being demonstrated; it therefore appears to have promise in this capacity (13).
Statistically significant reduction in pulmonary capillary wedge pressure -- Statistically significant increase in diuresis -- Trend toward reduction in right atrial pressure -- Trend toward increase in cardiac output -- No hypotension -- No change in serum creatinine About the Study The objective of the Phase 2a study is to assess hemodynamic and renal effects of CD-NP in patients with acute heart failure.
3) The National Institutes of Health Registry on Primary Pulmonary Hypertension defined it as a mean pulmonary arterial pressure greater than or equal to 25 mm Hg at rest, with a pulmonary capillary wedge pressure of less than or equal to 15 mm Hg.
In patients hospitalized with dyspnea at rest caused by acutely decompensated class IV CHF, those on Natrecor plus standard therapy had a quicker reduction in pulmonary capillary wedge pressure and improvements in dyspnea, without an increase in arrhythmias, compared with placebo plus standard care.
She required mechanical ventilation and her vital signs demonstrated marginal hemodynamics (blood pressure, 59/32 mm Hg; oxygen saturation, 95%; and pulmonary capillary wedge pressures in the 13-14 mm Hg range).