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About the Psoriasis Area and Severity Index (PASI) and Dermatology of Life Quality Index (DLQI)
Results of the 352-patient trial showed that 41% of patients treated with 30 milligrams of the drug, apremilast, twice a day, saw a 75% reduction in symptoms as measured by a score known as the Psoriasis Area and Severity Index (PASI-75) after 16 weeks.
The cohort had a mean Psoriasis Area and Severity Index score of about 24 and body surface involvement of about 30%.
The primary end point was the reduction of the Psoriasis Area and Severity Index (PASI) before and after treatment with Psoraxine.
The primary efficacy endpoints evaluated at weeks 12 and 24 included an Overall Lesional Assessment (OLA) of 0 or 1 (none or minimal), and Psoriasis Area and Severity Index (PASI) reduction of 50% and 75%.
The 'Know your PASI' follow-up survey, which was supported by Janssen, has revealed that patient awareness of Psoriasis Area and Severity Index (PASI) assessments has increased since the first survey in 2011.
Patients who initially received twice-weekly etanercept had a 78% improvement from baseline in the psoriasis area and severity index, while those on once-weekly therapy all along had a 74% improvement.
In this sub-analysis of 78 patients, more patients treated with REMICADE(R) showed a greater than or equal to 75 percent improvement from baseline to week 10 in the Psoriasis Area and Severity Index score (PASI 75 response) compared to placebo-treated patients.