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Twenty-five chapters start off with a historical overview and then address such topics as electronic CD of benzene and other aromatic chromophores for determination of absolute configuration, electronic circular dichroism of supramolecular systems, protein-nucleic acid interactions, carbohydrates and glycoconjugates, and drug discovery.
Herlihy noted that the combinatorial chemistry and screening technology utilized in the program may be applicable to numerous drug discovery targets which involve protein-protein and protein-nucleic acid interactions.
NIST's focus on precise measurement methods to define the structure, thermodynamics and kinetics of protein-protein and protein-nucleic acid interactions at the molecular level requires an NMR system with the highest sensitivity and stability for long-term measurements.