When these normal cellular prion precursors convert to pathogenic prion proteins, the transmissible conformations are characterized by [beta]-pleated sheets rather than the normal [alpha]-helix structure, and they do not elicit an immune response (4).
What does PRNP stand for?
PRNP stands for Prion Protein
This definition appears very frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
See other definitions of PRNP
We have 2 other meanings of PRNP in our Acronym Attic
- Power Range Nuclear Instrument
- Peoples' Republic of New Jersey
- People's Republic of North Korea
- Petroleum Research Newfoundland & Labrador (Canada)
- Pictured Rocks National Lakeshore (Munising, MI)
- Pipeline Recurrent Neural Network (wireless communications)
- Press Release News Network
- Pacific Regional Network Operation Center
- Petition for the Review of the Need for Placement (Denver, CO)
- Pollution and Natural Resources Program
- Pacific Rim National Park Reserve (Canada)
- Parks, Recreation and Neighborhood Services (California)
- Partially Resolved Numerical Simulation (aeronautics)
- Point Reyes National Seashore (California)
- Power Rangers Ninja Storm (TV show)
- Programs of Regional and National Significance (Center for Substance Abuse Prevention)
- Pseudo Random Noise Sequence
- Point Reyes National Seashore Association
- Plaque Reduction Neutralization Test
- Party of Romanian National Unity (est. 1990; Romania)
Samples in periodicals archive:
They then tested whether infectious prion proteins retained the ability to misfold normal proteins in vitro.
RT-QuIC, developed in recent years, detects when normal prion protein converts to an abnormal form
But scientists from the Medical Research Council stopped the spread of disease by genetically switching off production of normal prion protein.
Prion protein is a natural cellular protein that can become misfolded into infectious particles and cause bovine spongiform encephalopathy (BSE, or "mad cow disease") and a lethal variant of Creutzfeldt-Jakob disease (vCJD) in humans.
In the cattle brain disease BSE, its human equivalent vCJD, and the sheep disease scrapie, the infectious agents are thought to be rogue prion proteins.
A team of researchers said Tuesday that they recently succeeded in delaying the onset of symptoms of prion disease, widely known for brain-wasting effects in mad cow disease, by inoculating mice with normal prion proteins taken from other animals.
Related prion disorders include Gerstmann-Straussler-Scheinker syndrome, which is marked by cerebellar ataxia; and prion protein (PrP) and atypical forms of CJD caused by other mutations of the PrP gene (PRNP).