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Several platelet function assays are available, including light transmission aggregometry (LTA), vasodilator-stimulated phosphoprotein (VASP) phosphorylation, and the point-of-care VerifyNow P2Y12 assay (Accumetrics).
When there is history of nose and gum bleeding, platelet function assay by lumiaggregometer must also be performed.
Laboratory investigation is usually comprised of the prothrombin time (PT), activated partial thromboplastin time (APTT) test, the platelet count, the bleeding time test (now mostly historical) and the platelet function assay (PFA) developed for the PFA-100 analyser (4).
The VerifyNow[R] System (Accumetrics, San Diego, CA, uSA) is based on the ultegra rapid platelet function assay (RPFA).
The differential diagnosis of a hemorrhagic disorder with normal baseline coagulation studies (PT, PTT, thrombin clot time, fibrinogen, platelet count, platelet function assay and/or bleeding time) is limited.
Accumetrics has developed the Ultegra(R) System and a series of novel platelet function assays for the cardiovascular and cerebrovascular market.
Rapid and simple platelet function assay to assess GPIIb/IIIa receptor blockade.
Platelet function assays are inherently variable, so this level of experience is critical to produce reliable and accurate platelet aggregation results.