What does P stand for?

Writing about their study in the journal Cell Stem Cell, the researchers said that they used sophisticated phosphoproteomic analyses to catalogued 2,546 phosphorylation sites on 1,602 phosphoproteins.

Herz C, Aumailley M, Schulte C et al: Kindlin-1 is a phosphoprotein involved in regulation of polarity, proliferation, and motility of epidermal keratinocytes.

Written for both new and experienced scientists, the text covers two-dimensional gel electrophoresis and protein phosphorylation, enrichment of phosphoproteins and peptides,quantitative analysis of phosphorylation by labeling and MS analysis, antibody and kinase arrays, bioinformatics and phosphosite prediction, identification of phosphoproteins by mass spectrometry, and various chemical tagging strategies.

In partnership with scientists at the Brain Research Centre at the University of British Columbia, Kinexus exploited its commercial Kinetworks(TM) phosphoprotein profiling service to discover a novel phosphorylation site on the abundant nuclear protein B23 (also known as nucleophosmin).

Through this proteomics approach, program scientists hope to pinpoint key phosphoproteins that could, for instance, be controlled with a specific drug to block tumor growth with few side effects, as opposed to poisoning both tumors and healthy cells with the harsh chemotherapy drugs used now.

8-kb messenger RNA transcript and encodes for a 53-kd nuclear phosphoprotein (hence, p53) of a 393-amino-acid sequence protein that is expressed at low levels in the wild type.

8 BRCA1 encodes an 1863 amino acid, 220 kDa phosphoprotein with an N-terminal RING finger domain that interacts with cell-cycle proteins, and an acidic C-terminal transcriptional activation domain.

Keywords: Stathmin, rat, brain, development, placenta Stathmin is a cytosolic phosphoprotein believed to be involved in intracellular signaling (Sobel 1991).