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Samples in periodicals archive:
Cyclic nucleotide phosphodiesterases in health and disease.
Structure based drug design is particularly important because phosphodiesterases comprise a large family of enzymes in the body and inhibition of some isozymes is undesirable due to side effects.
These gene families, which include G protein-coupled receptors, ion channels, kinases, nuclear receptors, phosphatases, phosphodiesterases, transporters, and proteases, contain the genes of greatest interest to the pharmaceutical industry as new drug targets.
Phosphodiesterases (PDEs) are the enzyme superfamily of drug targets that underlie PDE inhibitor, Viagra(R), in 1998.
13 /PRNewswire/ -- The 2nd Annual Phosphodiesterases in Drug Discovery & Development Conference is scheduled to take place November 8-9, 2004 in Philadelphia, PA.
Phosphodiesterases (PDEs) are a family of enzymes that metabolize the intracellular messengers cyclic AMP (cAMP) and cyclic GMP.
22 /PRNewswire/ -- Strategic Research Institute announces its inaugural Phosphodiesterases in Disease Conference, which will be held this Nov.
The company has applied the platform in a number of target families, including kinases, nuclear receptors, and phosphodiesterases.