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The Company informed that the global study will assess disease remission in patients with pemphigus vulgaris who are treated with subcutaneous ofatumumab as add-on treatment to oral steroids, which is the global standard-of-care.
Only between one and five people in a million in the country will get pemphigus vulgaris (PV) each year.
The global study will assess disease remission in patients with pemphigus vulgaris treated with subcutaneous ofatumumab as add-on treatment to oral steroids, the global standard-of-care.
1,2) Pemphigus vulgaris is the most common subtype and accounts for approximately 70% of pemphigus cases.
1) There have also been a few published reports of various unusual ophthalmic presentations of herpetic infection: recurrent HSV eyelid infection, (2) herpetic meibomianitis, (3) herpetic-associated refractory (to corticosteroids) pemphigus vulgaris involving the eyelids, (4) as well as other lesions simulating neoplasia in the genital and peri-anal areas.
Differential diagnosis for the bullous stage of bullous pemphigoid * Pemphigus vulgaris * Stevens-Johnson syndrome * Pseudoporphyria * Bullous drug eruption * Dermatitis herpetiformis * Paraneoplastic pemphigus * Bullous lupus erythematosus * Porphyria cutanea tarda * Bullous impetigo * Cicatricial pemphigoid * Epidermolysis bullosa
Pemphigus vulgaris in pregnancy: analysis of current data on the management and outcomes.
Desmoglein 3 protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris and plays important roles in human squamous cell cancer.