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Charles Janeway, Fotis Kafatos and Nobel laureate Jules Hoffman, helped define the role of pattern recognition molecules in first line host defense.
Well-illustrated with line drawings and clinical photographs, the topics include the barriers of the innate immune system to infection, pattern recognition molecules, phagocytes, interferons and other danger signals, the T-cell receptor and the generation of diversity, macromolecular antigen, immunoglobulin structure and classes, B cells and memory B cells, the secondary lymphoid organs, Type 1 to Type 4 hypersensitivity, tuberculosis, autoimmunity, tumors, vaccines and HIV.
Collectins and ficolins: sugar pattern recognition molecules of the mammalian innate immune system.