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Appropriate areas of research include, but are not limited to: 1) Characterization of host cells involved in the innate immune response to protozoa; 2) Identification of novel pathogen-associated molecular pattern recognition receptors on host cells; 3) Characterization of mediators of innate immunity that are produced by host cells stimulated by protozoa; 4) Elucidation of the intracellular signaling pathways in the mammalian innate immune cells that are stimulated by protozoa; 5) Comparison of human versus animal model molecular responses to protozoan pathogens or their components; 6) Human or animal model gene mutations or polymorphisms associated with distinctive innate immune responses to protozoa.
Specifically, the Company is developing products that combine a disease-specific antigen, to trigger an adaptive immune response, with proprietary compounds called Pathogen-Associated Molecular Patterns (PAMPs), to trigger the response through innate immune pathways.