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25) (26) Blocking pancreatic lipase causes some triglycerides to pass out of the body in the feces.
ARTICLE INFO Keywords: Obesity Liquorice Chalcones Isoliquiritigenin Pancreatic lipase ABSTRACT Twelve flavonoids (1-12), isolated from Glycyrrhiza glabra roots were evaluated for their pancreatic lipase (PL) inhibitory activity in vitro.
Laboratory findings showed an amylase level of 477 mg/dl (normal <125 mg/dl), pancreatic lipase 292 U/L (0-60 U/L), pancreatic amylase 81 U/L (17-115 U/L).
Secretion of pancreatic lipase and colipase from rat pancreas.
Orlistat (Xenical) is a pancreatic lipase inhibitor.
The currently marketed pancreatic lipase inhibitor Orlistat, is associated with oily incontinence, caused by mal-absorbed triglycerides.
Inhibits pancreatic lipases, blocking absorption of about one-third of fat consumed.
The investigational drug candidate, GT389-255, has a dual mechanism of action, serving as a pancreatic lipase inhibitor and a fat-binder.