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Anil Rustgi, MD, Chief, Division of Gastroenterology from the Perelman School of Medicine at the University of Pennsylvania, and colleagues studied the molecular changes of exocrine cells during inflammation, so-called acinar-ductal metaplasia (ADM), a prelude to pancreatic ductal adenocarcinoma.
Summary: TEHRAN (FNA)- Researchers identified a new target to improve treatment of pancreatic ductal adenocarcinoma cancer, which accounts for more than 95 percent of pancreatic cancer cases.
Its presence is associated with a range of cancers, including pancreatic ductal adenocarcinoma, mesothelioma, epithelial ovarian cancer, and lung adenocarcinoma.
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways.
From July 2000 to January 2007, a total of 1088 patients from 16 countries with pancreatic ductal adenocarcinoma with R0 or R1 (35%) resection margins were randomised within 8 weeks of surgery to receive treatment with either 5-FU/FA or gemcitabine for 6 months.
With its tumor-targeted doxorubicin conjugate aldoxorubicin, CytRx has initiated an international Phase 2b clinical trial as a treatment for soft tissue sarcomas, has completed its Phase 1b/2 clinical trial primarily in the same indication, and has initiated a Phase 1b pharmacokinetics clinical trial in patients with metastatic solid tumors, a Phase 2 trial for patients with advanced pancreatic ductal adenocarcinomas and a Phase 1b study of aldoxorubicin in combination with doxorubicin in patients with advanced solid tumors.
Pancreatic ductal adenocarcinoma (PDAC)  is the fourth-leading cause of cancer mortality, with a 5-year survival rate of <5% (1).
Pancreatic ductal adenocarcinoma is the most common type of pancreatic cancer and carries the worst prognosis of any cancer, even when diagnosed early.