CHICAGO - Combined treatment with allopurinol and the novel purine nucleoside phosphorylase inhibitor BCX4208 significantly lowered serum uric acid levels in gout patients who had failed to respond to allopurinol alone, according to findings from a randomized placebo controlled trial involving 278 adults.
What does NP stand for?
NP stands for Nucleoside Phosphorylase
This definition appears frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
See other definitions of NP
We have 60 other meanings of NP in our Acronym Attic
- Not Possible
- Not Present
- Not Provided
- Notary Public
- Notes Payable
- Noteworthy Practice
- Notice Period
- Noun Phrase
- Now Playing
- Nuclear Power
- Null Pointer
- Number of Pitches (baseball)
- Number Pooling
- Number Portability (Mobile Services)
- Numbering Plan
- Nurse Practitioner
- Nutrification Potential (semiconductors)
- Occupation Newspaper (Scott Catalogue prefix; philately)
- Noise Pollution and Abatement Act of 1970
- Nantucket Planning and Economic Development Commission (Massachusetts)
Samples in periodicals archive:
Instead, the parasite must make purines indirectly, by using an enzyme called purine nucleoside phosphorylase (PNP) to make a purine precursor called hypoxanthine.
Fodosine(TM) is a purine nucleoside phosphorylase (PNP) inhibitor, which functions by blocking the DNA synthesis machinery of the body's T-cells.
Forodesine, a purine nucleoside phosphorylase (PNP) inhibitor which functions by blocking the T-cell's ability to synthesize DNA, was granted orphan status for treatment of T-cell non-Hodgkin's lymphoma, including cutaneous T-cell lymphoma, in February, 2004.
BioCryst currently has two late-stage development programs: peramivir, a viral neuraminidase inhibitor for the treatment of influenza, and ulodesine, a purine nucleoside phosphorylase (PNP) inhibitor for the treatment of gout.
BioCryst has progressed two novel compounds into late-stage pivotal clinical trials; peramivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL).
The study, which evaluated the pharmacokinetic profile for this oral formulation, measured BCX-4208 inhibition of the target enzyme purine nucleoside phosphorylase (PNP), and included detailed safety evaluations of renal and liver function, hematologic parameters, immunological markers, and cardiac function as measured through continuous ECG monitoring, including detailed QTc evaluations.
BioCryst currently has two late-stage programs: peramivir, a viral neuraminidase inhibitor for the treatment of influenza, and ulodesine (BCX4208), a purine nucleoside phosphorylase (PNP) inhibitor for the treatment of gout.