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One remarkable example occurred after the commercial availability of high-quality chemical probes for a subset of nuclear receptor proteins.
More specifically, ligand binding to a nuclear receptor results in a conformational change in the receptor, which, in turn, activates the receptor, resulting in up-regulation or down-regulation of gene expression.
Van Andel Research Institute (VARI) investigators came to the conclusion after mapping the structure and function of the so-called "orphan" nuclear receptor TR4.
Organon (Oss, Netherlands) has patented a protein having an amino acid sequence as in SEQ ID 7, 8, 11 or 12, similar proteins, naturally occurring variants and homologous functional equivalents thereof, as well as the use of a polynucleotide encoding such protein, for use in an assay and for use in a method of modulation of transcriptional activity promoted by a responsive nuclear receptor and a coactivator, which coactivator is the mentioned protein and is named COASTER, and which nuclear receptor is preferrably a steroid receptor.
The nuclear receptor superfamily: the second decade.
CYP26 inhibitors are expected to raise endogenous levels of both all-trans and 9-cis retinoic acid in cells expressing the enzyme and thereby activate both RAR and RXR nuclear receptor pathways in a cell- and tissue-specific fashion.
Such nuclear receptors are even more ancient than steroid receptors, and they bind to molecules that are simpler than steroid hormones.
the industry's leading provider of cell-based nuclear receptor reporter assay products and services, has added all nine retinoid receptor assays to the company's significant suite of kits and screening services.