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FAK is a non-receptor tyrosine kinase that regulates tumor cell proliferation and invasion.
Apart from being highly proliferative, such breast cancers are also associated with increased invasiveness and metastatic potential mediated by the Rho GTPases such as Cdc42, which drives migration via a non-receptor tyrosine kinase now known as TNK2.
Exposure to R5 gp120 and X4 gp 120 resulted in activation of pro line-rich tyrosine kinase 2 (Pyk2), a non-receptor tyrosine kinase related to focal adhesion kinase.