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Some progress has been demonstrated recently by using a less aggressive, non-myeloablative preparative regimen, followed by an infusion of unmanipulated bone marrow and the post-transplant use of a common chemotherapy drug, cyclophosphamide (Cy), but relapse is relatively common, especially in those with high-risk myeloid malignancies.
Nine years after the original diagnosis she was prepared for and received a non-myeloablative stem cell transplant.
All patients in the study, ranging in age from 16 to 45, were treated at the NIH with what researchers call a non-myeloablative or "mini" transplant, along with an immune-suppressing drug called rapamycin.
Tandem Autologous Hematopoietic Stem Cell Transplants (AuHCT) With or Without Maintenance Therapy (auto-auto) Versus Single AuHCT Followed by HLA Matched Sibling Non-Myeloablative Allogeneic HCT (auto-allo) for Patients With Standard Risk (SR) Multiple Myeloma (MM): Results From the Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 Trial [Abstract 41] Multiple myeloma is a form of blood cancer characterized by the overproduction of plasma cells in the bone marrow.
The researchers also sought to investigate the safety and tolerability of autologous non-myeloablative haemopoietic stem cell transplantation.
The procedure is called autologous non-myeloablative haematopoietic stem-cell transplantion.
5:00pm Oral Session: Clinical Care - Transplantation Regimen Toxicities and Engraftment: Preparative Regimens Y-90-Ibritumomab Tiuxetan, Fludarabine and TBI Based Non-Myeloablative Allogeneic Transplant Conditioning for High-Risk B-Cell Lymphoma Ajay K.
Rosenberg has identified and characterized a number of melanoma tumor-associated antigens, including gp100 and MART-1, and has developed a lymphodepleting non-myeloablative regimen used for adoptive cell therapy (ACT).