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Key clinical point: A 70-gene signature screen for chemotherapy guidance for node-negative breast cancer patients did not lead to better outcomes compared with a free online tool or giving all patients chemotherapy.
Key clinical point: A 70-gene signature screen for chemotherapy guidance for node-negative breast cancer patients did not lead to better outcomes, compared with a free online tool or giving all patients chemotherapy.
The clinicopathologic characteristics and prognostic significance of triple-negativity in node-negative breast cancer.
The trial followed 1,234 women who had node-negative breast cancer with tumors smaller than 5 cm and negative margins after breast-conserving surgery.
Although patients with node-negative breast cancer have an excellent prognosis, up to 25% to 30% of these patients will develop local recurrences or distant metastases within 10 years.
An article in the May 14, 2008 issue of the Journal of the American Medical Association reported that screening combining ultrasound (US) with mammography was better than mammography alone in depicting small, node-negative breast cancers not seen on mammography in women at high risk of breast cancer.
Of 427 MammaPrint gene profiles obtained from 812 patients with node-negative breast cancer, 30% of the results were discordant with the Dutch treatment guidelines.
In a study of women with axillary lymph node-positive or high-risk, lymph node-negative breast cancer, treatment with paclitaxel every week rather than every 3 weeks following adjuvant chemotherapy improved both overall and disease-free survival.