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Hydrogen peroxide is the analyte used in this research, and the aim of the research was to measure the analyte in nanomolar scales.
Nanomolar levels of this protein increase uncoupling protein 1 (UCP1) in cultures of primary white fat cells by 50 fold or more, resulting in very large increases in uncoupled respiration.
The authors showed that Karyopharm's SINE compounds induced apoptosis at nanomolar levels in AML cell lines and in AML blasts from patients.
10] nanomolar concentration of dexamethasone required to suppress phytohemagglutinin-induced lymphocyte proliferation by 50%--the higher the concentration, the more insensitive the lymphocytes are to dexamethasone.
A novel finding in those with severe preeclampsia was the presence of nanomolar amounts of free hemoglobin; functional data suggest this is not only a marker for severe preeclampsia, but a cause of some neurologic manifestations of the condition.
In a company presentation at the BioEquity Europe investor conference, the company reported that its CYC400 drug discovery program succeeded in generating multiple novel specific CDK inhibitors with some achieving picomolar potency in enzymes and nanomolar potency against tumor cell lines.
Triad Therapeutics (San Diego, CA; 858-457-0100) announced that it was awarded a key patent related to its use of NMR spectroscopy for the design of nanomolar level inhibitors for a broad class of protein drug targets.
Cro binds to its operator DNA as a dimer at nanomolar concentrations but is mostly monomeric in the absence of DNA.