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Neurologists, pediatricians, behavioral psychologists, geneticists, and others from Italy and the US discuss evaluating children with intellectual disabilities, the biological profile of Down Syndrome, neurobiological advances in the Fragile X family of disorders, idiopathic hypoparathyroidism and chromosome 10p deletion, cognitive enrichment, rehabilitation issues, narrative based medicine, and life span development in Turner Syndrome, Klinefelter Syndrome, XYY, Nance-Horan Syndrome, and interstitial deletion of chromosome 21.