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Primer name Primer sequence homo Mdr1-F GTGTGGTGAGTCAGGAACCTGTA homo Mdr1-R TCTCAATCTCATCCATGGTGACA homo MRP1-F CCTCAGCATCTTCCTTTTCATGT homo MRP1-R TCCTGAGTCCCGTTGACGAT homo MRP3-F GGAGTCGCTTTCATGGTCTTG homo MRP3-R TGATGCGCGAGTCCTTCA homo MRP4-F CTTCTTCCCCTCAGCCATTG homo MRP4-R ACGGTTGCGCTGTGATATCTC homo MRP6-F TTAGACGCGAGAGGTCCATCA homo MRP6-R CGTATTGGATGCTGTCCTTTCC homo GAPDH-F ACACCCACTCCTCCACCTTT homo GAPDH-R TAGCCAAATTCGTTGTCATACC Mdr, muti-drug resistance gene; MRP, multidrug resistance protein.
In cancer cells, ABC transporters such as P-glycoprotein (P-gp; MDR1, ABCB1), breast cancer resistance protein (BCRP; ABCG2), and multidrug resistance protein 2 (MRP2; ABCC2), eliminate intracellular drug load by transporting substrates (including anthracyclines and taxanes) across the plasma membrane and out of the cell--preventing anti-cancer drugs from reaching their cellular targets [4,5].
Among their topics are using genetically engineered mouse models to study drug resistance in breast cancer, the flow cytometric evaluation of multidrug resistance proteins, drug ration- dependent antagonism as a new category of multidrug resistance and strategies for its circumvention, pharmaco-kinetic and pharmaco-dynamic implications of P-glycoprotein modulation, immuno-suppressors as multidrug resistance reversal agents, and overcoming multidrug resistance by RNA interference.
Louis have identified a multidrug resistance protein (MRP) in glial cells that prevents substances from entering into the brain.
Multidrug resistance protein 1 (MRP1), which is structurally similar to P-gp, is the product of the ABCC1 gene and can export anthracenedione, anthracycline, epipodophyllotoxin, vinca alkaloids, etc.
TOR is an atypical multidrug resistance protein that is found in at least two regions in Leishmania: the mitochondria and the Golgi/trans Golgi network.
NASDAQ: ISIP) today announced the signing of a license and research agreement with investigators at Queen's University in Kingston, Canada, granting Isis exclusive worldwide rights to develop and market oligonucleotide therapeutics targeting a novel multidrug resistance protein (MRP).
11 Multidrug Resistance Proteins of the ABCC Subfamily (Anne T.