The test is based on the conversion of lidocaine to its deethylated metabolite monoethylglycinexylidide (MEGX), primarily through the hepatic cytochrome P450 system.
What does MEGX stand for?
MEGX stands for Monoethylglycinexylidide (plasma component)
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Samples in periodicals archive:
Monoethylglycinexylidide (MEGX), the primary metabolite of lidocaine, is produced via oxidative N-deethylation catalyzed by cytochrome P450 (CYP) 3A4 (1).
The hepatic conversion of lidocaine to the metabolite monoethylglycinexylidide (MEGX)I is primarily catalyzed by the cytochrome P450 enzyme 3A4 in humans (1).
Monoethylglycinexylidide formation kinetics: a novel approach to assessment of liver function.
Specifically, the kinetics of the lidocaine metabolite monoethylglycinexylidide (MEGX) can be used to assess hepatocyte injury [22-24].
The hepatic conversion of lidocaine to its metabolite monoethylglycinexylidide (MEGX) is catalyzed by the cytochrome P450 enzyme CYP3A4 in humans.
For certain compounds such as propoxyphene and its metabolites, diphenhydramine, promethazine, and lidocaine and its major metabolite monoethylglycinexylidide, Remedi scored remarkably high.