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Dissocyanate antigen-stimulated monocyte chemoattractant protein-1 synthesis has greater test efficacy than specific antibodies for identification of clissocyanate asthma.
The expression of immunomodulatory membrane molecules such as inter-cellular adhesion molecule-1 (ICAM-1) by Western blot analysis, and the release of chemokines such as monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) through ELISA kits, were determined.
Monocyte chemoattractant protein-1 regulates migration and infiltration of monocytes into tissues where they replenish infection-fighting macrophages.
The main function of IL-17-secreting T cells is to mediate inflammation, by stimulating production of inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6, and inflammatory chemokines, including CXCL-6, CXCL-7, CXCL-8, IL-8 and monocyte chemoattractant protein-1 (MCP-1), and metalloproteinases that promote the recruitment of neutrophils and macrophages (recruited by Thl cells) resulting in inflammation and tissue pathology (Fig.
Other topics include intrathecal upregulation of monocyte chemoattractant protein-1 in amyotrophic lateral sclerosis, serum levels of interleukin-16 in lymphoid neoplastic diseases, and syndecans as modulators of chemokine function.
Deregulated expression of monocyte chemoattractant protein-1 (MCP-1) in arterial hypertension: role in endothelial inflammation and atheromasia.
With respect to inflammatory diseases of the kidney, leukocyte infiltration is mediated by proinflammatory chemokines, (19-23) and the chemokine monocyte chemoattractant protein-1 (MCP-1) has been shown to be pathogenic for kidney injury in murine lupus nephritis, and significantly associated with human SLE nephritis.
CAL also increased the expression of vascular cell adhesion molecule-1 (VCAM-1) and monocyte chemoattractant protein-1 (MCP-1).