However, it was previously unknown whether p53 can also activate oxidative stress-induced necrosis, a regulated form of cell death that depends on the mitochondrial permeability transition pore (PTP) pore.
What does MPTP stand for?
MPTP stands for Mitochondrial Permeability Transition Pore (microbiology)
This definition appears frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
See other definitions of MPTP
We have 14 other meanings of MPTP in our Acronym Attic
- Multimedia in Physics Teaching and Learning (European Physical Society Physics Education Division)
- Masters Program in Telecommunication Management
- Mechanical Pre-cutting Tunneling Method (mining)
- Multi-Parity Test Method
- Mashantucket Pequot Tribal Nation (Connecticut, USA)
- Multiprotocol Transport Network
- Methods and Procedures Technical Order
- 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (neurotoxin)
- Medical Proficiency Training Program
- Micro Payment Transfer Protocol
- Mobile Phone Telematics Protocol
- Murine Protein Tyrosine Phosphatase (molecular biology)
- Mail Preparation Total Quality Management
- Major Polymorphic Tandem Repeat
- Manpower, Personnel, and Training Resource Requirements
- Manpower, Personnel, & Training Resource Requirements Document
- Medical Practitioners Tribunal Service (UK)
- Metal Parts
- Metropolitan Police Trading Service (UK)
- Micro Processor Time Switch
Samples in periodicals archive:
More specifically, a generalised mega-channel, commonly referred to as the mitochondrial permeability transition pore (mPTP), assembles in the inner mitochondrial membrane (IMM) during ischaemic injury and significantly contributes to the observed changes in mitochondrial permeability.
Transgenic mouse models of human neurodegenerative disease are beginning to reveal possible principles governing the biology of selective neuronal vulnerability that implicate mitochondria and the mitochondrial permeability transition pore.
The mitochondrial permeability transition pore is modulated by oxidative agents through both pyridine nucleotides and glutathione at two separate sites.
This gene-regulated cell death pathway involves opening of the mitochondrial permeability transition pore without caspase activation and cytochrome c release.
The PBR is a component of the mitochondrial permeability transition pore, a protein located at the contact site between the outer and inner mitochondrial membrane, which is involved in apoptosis.
1997), increases reactive oxygen species (ROS) production, impairs mitochondrial respiration, causes ATP depletion, opens the mitochondrial permeability transition pore and makes the mitochondrial inner membrane abruptly permeable to solutes up to 1500 Da Qames et al.
The research revealed that brain mitochondria are specifically and powerfully protected by cyclosporins, through cyclosporins' unique ability to block the formation of the mitochondrial permeability transition pore or "megapore".