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The primary objective of the trial is to determine the Maximum Tolerated Dose (MTD), Dose-Limiting Toxicity (DLT), recommended dose and dosing schedule and safety profile of REOLYSIN(R) when administered in combination with carboplatin and paclitaxel.
Description of other effects of LGD1057 awaits accrual of additional patients and determination of the maximum tolerated dose in this ongoing study.
LOS ANGELES -- CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical company specializing in oncology, today announced the initiation of a Phase 1b clinical trial to determine the maximum tolerated dose and to evaluate preliminary efficacy of aldoxorubicin (formerly INNO-206) administered in combination with the commonly used chemotherapeutic agent doxorubicin in patients with advanced solid tumors who have failed other therapies.
Conducted by Kosan and Roche as part of a global partnership to jointly develop and commercialize KOS-862, the Phase I trials were designed to determine the maximum tolerated dose, toxicity profile, pharmacokinetics and pharmacodynamics of intravenous KOS-862.
The maximum tolerated dose in this study also was determined by diminished blood platelet levels.
Increasing doses of trastuzumab-MCC-DM1 are given to new patients until the maximum tolerated dose (MTD) is established.
A primary objective of the trial is to determine the maximum tolerated dose (MTD) of huN901-DM1 in multiple myeloma patients with this dosing schedule.
Another phase I study showed SGN-40 induces antitumor activity, is well-tolerated and a maximum tolerated dose has not been reached in patients with relapsed multiple myeloma.