Mannose-6-phosphate (M6P), a natural sugar, is known to isomerize to fructose-6-phosphate (F6P), an intermediate of glycolysis in the step prior to FBP.
What does M6P stand for?
M6P stands for Mannose-6-Phosphate
This definition appears frequently and is found in the following Acronym Finder categories:
- Science, medicine, engineering, etc.
We have 2 other meanings of M6P in our Acronym Attic
- Mark 5 Army Nerf Gun Corps
- Method 5 Acid Train
- Mode 5 Level 2
- Movimento 5 Stelle (Italian: 5 Stars Movement; political party)
- Major Sixth (music)
- Métropole 6 (French TV Network)
- Minor Sixth (music)
- Morphine-6-Glucuronide (molecule)
- M6 Membrane Extract (protein)
Samples in periodicals archive:
We believe BMN-701 has the potential to possibly deliver more enzyme to lysosomes compared to traditional mannose-6-phosphate targeted approaches using the recently acquired GILT technology.
The type 2 IGF receptor, also known as cation-independent mannose-6-phosphate receptor (IGF-R2/ M-6-P), is structurally and functionally different from the IGF-R1.
In vitro studies demonstrate that ZC-701 has more than ten times higher affinity for the mannose-6-phosphate receptor compared to Myozyme, which enables delivery of higher levels of enzyme to the lysosomes of muscle cells of Pompe patients.
ALDURAZYME uptake by cells into lysosomes is most likely mediated by the mannose-6-phosphate-terminated oligosaccharide chains of laronidase binding to specific mannose-6-phosphate receptors.
As Genzyme has presented at two scientific meetings, the Fabrazyme protein is fully sialylated, which reduces non-specific removal by the liver, and it has appropriate levels of mannose-6-phosphate to ensure uptake into the proper compartment (lysosomes) of the target cells.
Canfield, a recognized leader in the field of LSDs, is responsible for Novazyme's mannose-6-phosphate (M6P) technology that was developed at the University of Oklahoma.