Summary of Virologic Response by Treatment Regimen + SOC (Pegasys+ Copegus) N HCV RNA <LLOQ(1) (<43 IU/mL) N (%) HCV RNA < LLOD(2) (<15 IU/mL) N (%) Viral Rebound Placebo + RTV 5 1/5 (20%) 1/5 (20%) 0 100 mg danoprevir + 100 mg RTV (twice daily) 9 7/9 (78%) 6/9 (67%) 0 200 mg danoprevir + 100 mg RTV (once daily) 8 5/8 (63%) 4/8 (50%) 0 200 mg danoprevir + 100 mg RTV (twice daily) 8 8/8 (100%) 8/8 (100%) 0 Un-boosted 900 mg (twice daily) (historical)(3) 7 3/7 (43%) 1/7 (14%) 0 (1) LLOQ = lower limit of quantification by Roche TaqMan Assay (<43 IU/mL) (2) LLOD = lower limit of detection by Roche TaqMan Assay (<15 IU/mL) (3) LLOQ <25 IU/mL and LLOD = 9.
What does LLOQ stand for?
LLOQ stands for Lower Limit of Quantification
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- Lower Limit of Detection
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- Long Legged Older Man (Japanese manga)
- Latino Leadership Opportunity Program (University of Massachusetts)
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- Landowner Liability Protections
- Law Library Publications (American Association of Law Libraries)
- Lead Logistics Provider
- Leadless Leadframe Package (National Semiconductor Corporation)
- Leased Long Lines Program
- License Limitation Program
- Life Limited Part (aircraft)
- Lifelong Learning Plan
Samples in periodicals archive:
This value is sometimes referred to as "functional sensitivity," a term that unfortunately confounds sensitivity and lower limit of quantification.
09 [micro]g/mL, and a lower limit of quantification in undiluted serum specimens of 3.
INFORM-1 Results Viral Kinetic Performance of Twice-Daily Regimens The full dose combination of RG7128 1000mg and RG7227 900mg administered twice-daily without pegylated interferon or ribavirin, the current standard of care for HCV, for 13 days resulted in 88% of HCV-positive treatment-naive patients achieving HCV RNA below the lower limit of quantification (LLOQ; <43 IU/mL), and 63% of patients having HCV RNA below the lower limit of detection (LLOD; <15 IU/mL).
The lower limit of quantification (LLOQ) was determined as the lowest concentration of the calibration curve consistently yielding results within 20% of the nominal concentration and a precision [less than or equal to] 20%.
Further dilutions of this stock solution were prepared to assess the lower limit of quantification (LLOQ).
Approximately 68 percent (23/34) of patients receiving this combination regimen achieved viral clearance at week 24, utilizing the TaqMan(R) assay's lower limit of quantification of 20 IU/mL.
The lower limit of quantification (defined as the concentration at which the CV does not exceed 20%; n = 15) was 0.