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Adjuvant treatment may not improve survival rate, on the other hand recent papers have demonstrated improvements with neoadjuvant radiotherapy treatment mostly in local relapse-free survival.
In addition to the absence of anemia, other factors that significantly increased local relapse-free survival were younger age at diagnosis and negative lymph node status.
The study concluded that hyperthermia added to radiation improved complete response (tumor disappearance) from 41% to 83%, local relapse-free survival from 24% to 68% and overall survival at 5 years from 0% to 53%, as compared to radiation treatments alone.
In phase III clinical trials where hyperthermia therapy was added to ionizing radiation treatments, hyperthermia improved local relapse-free survival for head and neck cancer from 24% to 68%, 2-year local control of melanoma from 28% to 46%, complete response for recurrent breast cancer from 38% to 60%, 2-year survival for glioblastoma (brain cancer) from 15% to 31% and 3-year survival for advanced cervical cancer from 27% to 51%, as compared to the use of ionizing radiation therapy alone.