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Additional in vitro testing involved testing of cyclooxygenase-2 (COX-2) and lipoxygenase inhibition, cellular antioxidant protection by the CAP-e bioassay, and formation of reactive oxygen species (ROS) by polymorphonuclear (PMN) cells by flow cytometry.
Relationship between lipoxygenase and human testicular cancer.
The investigators assayed peroxidase and lipoxygenase using color reactions.
This laboratory is studying the expression of prostaglandin H synthases and lipoxygenases in the development of colon, breast, and other cancers.
Arachidonic acid is metabolized to prostaglandins, leukotrienes, and epoxyeicosatrienoic acid by cyclooxygenase, lipoxygenase, and epoxygenase, respectively.
Expression of lipoxygenase in human prostate cancer and growth reduction by its inhibitors.
Reductive inactivation of soybean lipoxygenase 1 by catechols: a possible mechanism for regulation of lipoxygenase activity.
Lipoxygenase catalyzes the formation of such aldehydes as hexanal,(E)-2-hexenal, (E,Z)-2,6-nonadienal and (E)-2-nonenal.