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Leukocyte adhesion deficiency (LAD) is a genetic disease inherited as an autosomal recessive condition in which the expression of glycoprotein adhesion molecules on leukocytes is reduced.
Foamy viruses for delivering new genes into cells to correct LAD is successful A study reporting the first successful gene therapy using foamy viruses for delivering new genes into bone marrow stem cells of dogs, and correcting a leukocyte adhesion deficiency (LAD) will be presented on Friday, June 2 at the 9th Annual Meeting of the Society of Gene Therapy (ASGT) in Baltimore.
Another researcher was discussing Leukocyte Adhesion Deficiency in humans, and Kehrli thought the symptoms of human LAD were similar to those of a calf that had died at the USDA-ARS National Animal Disease Center in Ames, Iowa, where he works.