What does LV stand for?

Poster presentation details are as follows: Randomized Phase 2 study of Picoplatin in Combination with 5-fluorouracil and Leucovorin (FOLPI) as a Neuropathy-Sparing Alternative to mFOLFOX-6 as First-line Therapy for Colorectal Cancer (CRC) Abstract #B49 R.

Standard first-line treatments including fluorouracil (5-FU) with leucovorin (LV) and irinotecan or oxaliplatin, alone or combined with bevacizumab, have resulted in a median overall survival (mOS) greater than 20 months [3-9].

Of the 348 tumor samples that expressed normal KRAS, one-year progression-free survival rates were 25% and 43% for patients with normal KRAS tumors receiving FOLFIRI (fluorouracil, leucovorin, and irinotecan) and the combination of cetuximab plus FOLFIRI, respectively.

7,8,18,19) Early evidence of oxaliplatin activity in combination with 5-FU was provided by clinical studies employing various infusional and chronomodulated OXP/5-FU and leucovorin (LV) schedules.

The promising approach adds the new cancer drug called oxaliplatin (Eloxatin) to usual doses of 5-fluorouracil and leucovorin.

The agency objected to a brochure advertising the company's Methotrexate (methotrexate sodium injection), Leucovorin (leucovorin calcium injection), and Amicar (aminocaproic acid) that failed to provide any risk information about the drugs.

The Food and Drug Administration (FDA) today announced the approval of Eloxatin (oxaliplatin) injection for use in combination with infusional 5-fluorouracil (5-FU) and leucovorin for the treatment of patients with colorectal cancer whose disease has recurred or become worse following initial therapy with a combination of irinotecan with bolus 5-FU and leucovorin.

UFT and Leucovorin have been proven in phase II trials to have acceptable toxicity and response in colorectal cancers, and seem to afford a treatment alternative to infusional 5-FU.