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Tetracyclines were associated with a variety of heart defects plus left ventricular outflow obstruction defects, septal heart defects, and oral clefts.
Mechanism of left ventricular outflow obstruction in patients with obstructive asymmetric septal hypertrophy (idiopathic hypertrophic subaortic stenosis).
Women were more likely to have left ventricular outflow obstruction, possibly because of the smaller dimensions of their left ventricular cavities.
Left ventricular outflow obstruction is present in about 40% of HC patients of advanced age, suggesting that subaortic gradients may be well tolerated for long periods without adverse consequences.