The Columbia team found that isocitrate dehydrogenase expression significantly increases in tumors with the recurrent mutations.
What does ICD stand for?
ICD stands for Isocitrate Dehydrogenase
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- International Classification of Diseases, Version 8 (World Health Organization)
- International Classification of Diseases, Ninth Revision, Clinical Modification
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Samples in periodicals archive:
identified a genetic mutation in glioblastomas and other brain tumors that alters the function of an enzyme known as an isocitrate dehydrogenase.
Dehydrogenation and then decarboxylation, Unstable oxalosuccinate in between, Isocitrate dehydrogenase forms NADH, Brings [alpha]-ketoglutarate on the scene.
Notably, these effects were reversible when treated with an isocitrate dehydrogenase 1 (IDH1) inhibitor discovered, developed and provided by Agios, which blocks the production of 2-HG.
Isocitrate dehydrogenase generates NADPH to support fatty acid synthesis and was also more highly expressed in mammary than liver tissues.
We have recently used just such a method, coupled with a Laue x-ray diffraction experiment, to define the structure of the Miehaelis complex of the enzyme isocitrate dehydrogenase (IDH), its substrate isocitrate, cofactor nicotinamide adenine dinucleotide phosphate (NADP+) and magnesium .
Called an "oncometabolite" for its role in cancer metabolism, the 2-hydroxyglutarate (2HG) metabolite is produced at high levels by cancer-associated mutations in an enzyme known as isocitrate dehydrogenase (IDH).
the leader in metabolomics, biomarker discovery and analysis, announces the publication of "Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome", in The Proceedings of the National Academy of Sciences (PNAS 108 (8) 3270-3275).