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The trial - called SCIPIO for Stem Cell Infusion in Patients with Ischemic CardiOmyopathy - was a randomized open-label trial of cardiac stem cells (CSCs) in patients who were diagnosed with heart failure following a myocardial infarction and had a LVEF of 40 percent or lower; the normal LVEF is 50 percent or higher.
Ischemic cardiomyopathy is the term for impaired heart muscle tissue with a reduced capacity to pump blood effectively.
This differentiation is clinically important as ischemic cardiomyopathy (CM) is associated with shorter mean survival.
There were no wall motion abnormalities noted at target heart rate; hence, ischemic cardiomyopathy was considered unlikely.
The patient's Death Certificate, completed by his attending physician, showed the cause of death as "congestive heart failure following an acute myocardial infarction stemming from his prolonged history of ischemic cardiomyopathy.
Also, two people in the low-carbohydrate group died, one of complications from hyperosmolar coma at 5 months into the study and one of sudden severe ischemic cardiomyopathy at 10 months into the study.
Thoratec Corporation, Pleasanton, CA, announced that a 61-year old German man with ischemic cardiomyopathy became the first patient in Europe to be implanted with its HeartMate II left ventricular assist system.
For example, survival rates show improvement in ischemic cardiomyopathy patients with post-op LVESVI of less than or equal to 70 mL/m2.