This subtype is known to resemble a benign lipoma on CT and MRI; however, liposarcomas may show enhancement of septations and of intratumoral nodular densities on gadoliniumenhanced, T1-weighted (T1W), fat-suppressed MRI.
On the other hand, the tumour vasculature becomes more mature, the intratumoral pressure diminishes, and chemotherapy drugs more easily penetrate the tumour.
Assessment of Immunohistochemical Intratumoral Heterogeneity Intratumoral heterogeneity was assessed using the Ki-67 counts obtained from the 10 HPFs investigated from each tumor biopsy specimen.
Three IL13-PE38 abstracts (#1841, #2087 and #2088) were published in the 2002 ASCO Program Proceedings -- two revealing Phase I/II data on intratumoral infusion of IL13-PE38 in malignant glioma, a rare and terminal form of brain cancer for which there is no known cure (Abstracts #2087, #2088), and one studying the clinical and pharmacokinetic effects of systemic administration of IL13-PE38 in advanced renal cell carcinoma (Abstract #1841).
1) reported that intratumoral administration of THC induces apoptosis of transformed neural cells in culture, and also induces a considerable regression of malignant gliomas in Wistar rats and in mice deficient in recombination activating gene 2.
Iva Toudjarska, presented the following data: * ALN-VSP-mediated silencing of KSP in both HCC and colorectal carcinoma models, resulting in the accumulation in tumor cells of aberrant mitotic figures, also known as monoasters, a hallmark of KSP inhibition; * monoaster formation in tumor cells within lymph node metastases derived from the orthotopic liver tumors, demonstrating the ability of LNPs in general, and ALN-VSP in particular, to achieve effective delivery in extra-hepatic tumor sites; * marked anti-angiogenic effects resulting from ALN-VSP treatment, including reductions in both tumor microvessel density and intratumoral hemorrhage; and * similar anti-angiogenic results with an LNP containing only the VEGF siRNA, demonstrating that the vascular effects are due to VEGF silencing.
