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Samples in periodicals archive:
3120+1G>A, intervening sequence 16) illustrates this concept well.
The intervening sequence RNA of Tetrahymena is an enzyme.
The European Patent Office did, however, clarify the scope of the claims to cover self-splicing intervening sequence derived ribozymes, which does not significantly narrow the scope of coverage.
b) Known polymorphism in HFE intervening sequence (intron) 2 (IVS2) (39).
EP-0291533 in having the claims limited to ribozymes derived from wildtype self-splicing intervening sequences (IVS).
The gene behind the membrane molecule also contains distinct parts, called exons, separated by much longer stretches of DNA, called introns or intervening sequences, that do not code for any portion of the protein molecule.
A minigene construct spanning exons 8-11 and the intervening sequences was cloned into the pcDNA3.
The retention of this novel transcript demonstrated that the antisense compound was inhibiting splicing, the process by which the intervening sequences are normally removed from the mRNA.