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With a lactic acid dehydrogenase level of 566 U/L, the International Prognostic Index was low risk (1 point).
Is the Mantle Cell Lymphoma International Prognostic Index (MIPI) adequate to stage this cancer?
15,16] The goal of this study was to review the cases of testicular lymphoma diagnosed at our institution to add to the current knowledge of the presentation, workup, treatment and outcome of this disease, and to determine if there was a significant difference in survival by stage and International Prognostic Index (IPI) score.
And while risk status, assessed by the International Prognostic Index (IPI), was rated favorable in the majority of patients, limited statistical analysis showed that patients with unfavorable IPI ratings also failed to benefit from HDC+ABMT.
Physicians currently assess a patient's DLBCL risk of disease progression and outcome by using the International Prognostic Index (IPI), but more accurate classification of patients based on the underlying tumor biology is needed to allow physicians and patients to make more informed treatment decisions.
Risk factors for CNS involvement as determined in this study included blastic morphology, high MIB-1/ Ki-67 immunostaining, high serum lactic acid dehydrogenase (LDH) levels, and a high-risk International Prognostic Index score.
Although rare, DLBCL is the most common sub-type of non-Hodgkin's lymphoma (NHL) of which approximately 50% of high-risk patients (high-risk is defined as having an International Prognostic Index score of 3-5) relapse within three years after receiving first line therapy.
The poor prognostic factors were predicted by the international prognostic index and not by the bulk of the mediastinal disease.