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The Intergroup Exemestane Study (IES)  reported, at 58 months, a 7% fracture rate on the steroidal AI exemestane, compared to a lower fracture rate (5%) on tamoxifen (P<0.
May 12 /PRNewswire/ -- The International Collaborative Cancer Group, in collaboration with the Institute of Cancer Research Clinical Trials and Statistics Unit, is running the Intergroup Exemestane Study (IES).
In June, the landmark Intergroup Exemestane Study also found that switching to Aromasin cut the risk of death by 17 per cent compared with remaining on tamoxifen.
In the Intergroup Exemestane Study (IES) of more than 4,700 women with estrogen-receptor-positive breast cancer, patients who switched to exemestane after 2 or 3 years of taking tamoxifen for the remainder of 5 years total treatment experienced a 32% reduction in the risk of recurrence of the disease at 3 years, compared with those continuing tamoxifen for 5 years.
Additional Results from the 91-Month Median Follow-up of the Intergroup Exemestane Study (IES) and the Tamoxifen, Exemestane, Adjuvant, Multicenter (TEAM) Study Demonstrate Benefits of Aromasin in Estrogen-Receptor Positive/Unknown Postmenopausal Early Breast Cancer Patients
oral presentation, titled, "Disease related outcome with long term follow-up: an updated analysis of the Intergroup Exemestane Study (IES)" and several poster sessions listed below.
The Intergroup Exemestane Study (IES) shows a borderline significant improvement in overall survival in the subset of steroid hormone receptor-positive or unknown breast cancer.
The approval was based on the Intergroup Exemestane Study (IES) that showed patients who switched to Aromasin after two to three years of tamoxifen had a 31 percent better probability of disease-free survival than those who remained on tamoxifen.