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Samples in periodicals archive:
The ONWARD (Oral Cladribine Added ON To Interferon beta-1a in Patients With Active Relapsing Disease) study: a Phase II placebo-controlled trial designed primarily to evaluate the safety and tolerability of adding Cladribine Tablets treatment to patients with relapsing forms of MS, who have experienced breakthrough disease while on established interferon-beta therapy.
Interferon-beta is an injectable treatment for multiple sclerosis (MS).
Multiple sclerosis (MS) has become more manageable, in large part because of the availability of disease-modifying drugs typified by the interferon-betas.
have demonstrated in an in vivo model that a new variant of recombinant interferon-beta reduces the immunological response to the protein.
The multi-center, open label phase IIb clinical trial will determine the safety and efficacy of Alferon N Injection, a highly purified mixture of natural alpha interferons, in patients with relapsing-remitting MS, who have discontinued interferon-beta therapy because of clinical progression or intolerance, or who have developed neutralizing antibodies to interferon-beta.
along with collaborators from the University Campus Bio-Medico, Rome have identified an immunogenic region (called an "epitope") in the human interferon-beta protein sequence that activates human CD4+ helper T cells, the obligatory first step in the cascade that can lead to the production of neutralizing antibodies that inhibit the beneficial actions of interferon-beta.
AMEX:HEB) announced today that it submitted to the FDA a new clinical Protocol entitled "A multi-center, open label, study of Alferon N Injection(R) in subjects with relapsing-remitting multiple sclerosis, who have discontinued interferon-beta therapy because of clinical progression or intolerance, or who have developed neutralizing antibodies to interferon-beta.