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8) Human genes: IMPDH, inosine 5'-monophosphate dehydrogenase 1; CYP3A5, cytochrome P450, family 3, subfamily A, polypeptide 5; UGT1A9, UDP glucuronosyltransferase 1 family, polypeptide A9; ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (formerly MDRR1); IL10, interleukin 10; TGFB1, transforming growth factor, beta 1; CYP3A4, cytochrome P450, family 3, subfamily A, polypeptide 4; ABCC2, ATP-binding cassette, subfamily C (CFTR/MRP), member 2 (formerly known as MRP2); TPMT; thiopu rine S-methyltransferase.
3-Hydrogenkwadaphnin targets inosine 5'-monophosphate dehydrogenase and triggers post-Gl arrest apoptosis in human leukemia cell lines.
Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice.