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A major breakthrough in understanding the molecular biology of CLL came in 1999, when 2 laboratories (2, 3) independently reported stratification of CLL into 2 patient groups according to the mutational status of genes for immunoglobulin heavy chain variable regions.
Highly Sensitive Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia Using Next-Generation Sequencing of Immunoglobulin Heavy Chain Variable Region (Abstract 2540) Malek Faham, MD, Ph.
Next-Generation Sequencing of Immunoglobulin Heavy Chain Variable Region in Diagnostic Samples of Pediatric Acute Lymphoblastic Leukemia Identifies Hundreds of Clonal Subpopulations with Multiple Immunophenotypes will be presented Saturday, December 10, 2011: 5:30 PM-7:30 PM, #1436.