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About A4250 A4250 belongs to a class of inhibitors of the ileal bile acid transporter (IBAT, syn.
Elobixibat is acting locally in the gut with minimal systemic exposure and modulates the enterohepatic circulation of bile acids by inhibiting the Ileal Bile Acid Transporter (IBAT) thereby increasing colonic fluid secretion and motility.
4) years] and patients who had undergone resection of terminal ileum, for whom malabsorption of bile acids would be expected owing to the loss of ileal bile acid transporter [22 males, 28 females, mean (SD) age 41.