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This may explain the reduction of IL1, IL6 and 1L8 at protein levels.
Extrathymic influences regulating the secretory function of thymic epithelial cells and the stepwise evolution of T cells can be ascribed to circulating interleukins, mainly IL1 and IL2, derived from activation and secretion of leukocytes in the periphery.
In Group 1, the increased-inflammation group, macrophages showed a decrease of inflammatory activation; in Group 2, macrophages showed an increase of the inflammatory genes IL1 and TLRs when either 1alpha,25-Dihydroxyvitamin D3 or resolvin D1 were added.
TNF alfa blokerleri, Th1 paterninden (Orn: IFN gama, IL1, TNF) Th2 paternine (orn: IL 4, 5, 6, 10, 13) kaymaya neden olmakta, bu da antikor iliskili immuniteye neden olabil-mektedir (15).
IL1 beta had more effect on the production of MMP3 while TNF had more effect on MMP1 production.
Kronik inflamasyonun metabolik ve vaskuler bozukluklarin gelisiminde rol oynadigi dusunulmekte olup proinflamatuar sitokinlerin (TNF alfa, IL1, IL6) aterogenez ve periferik insulin direncine dolayisiyla da hipertansiyon ve tip 2 diyabet gelisimine yol actigi one surulmektedir (12,13).
Bazi yazarlar tarafindan RA'nin ekstaartikuler manifestasyonu olarak kabul edilen aterosklerozis (4-6) gelisimine klasik kardiyovaskuler risk faktorleri (dislipidemi, sigara, cinsiyet, yas, hipertansiyon) ve inflamatuar risk faktorleri (CRP IL1, IL6, TNFa) katkida bulunmaktadir (7, 8).
Research studies showed that VCAM-1 is not a constitutive adhesion molecule of human umbilical vein endothelial cells but is inducible by TNF-[alpha] & IL1 [32,33].